Article
Variability of age at onset in siblings with familial Alzheimer disease.
Archives of neurology - 1 Dec 2007
Gómez-Tortosa Estrella, Barquero M Sagrario, Barón Manuel, Sainz M Jose, Manzano Sagrario, Payno Maria, Ros Raquel, Almaraz Carmen, Gómez-Garré Pilar, Jiménez-Escrig Adriano
Abstract excerpt
BACKGROUND: Variability of age at onset (AO) of Alzheimer disease (AD) among members of the same family is important as a biological clue and because of its clinical effects. OBJECTIVE: To evaluate which clinical variables influence the discrepancy in AO among affected relatives with familial AD. SETTING: Clinical genetic project of Spanish kindred with AD conducted by 4 academic hospitals in Madrid, Spain....
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