Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.

doi:10.1177/089198879701000101

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Article

Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.

Journal of geriatric psychiatry and neurology - 1 Jan 1997

Lopez-Alberola R F, Barker W W, Harwood D G, Loewenstein D A, George-Hyslop P H, Tsuda T, Rogaeva E A, Duara R

Abstract excerpt

The features of Alzheimer's disease (AD) are very heterogenous, and some component of the variability of AD is likely to be related to genetic factors. To investigate this question, we evaluated 19 clinical neuropsychiatric and brain imaging features in 32 familial Alzheimer's disease (FAD) kindr...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Apolipoproteins E
Atrophy
Cerebral Cortex
Family
Female
Genetic Heterogeneity
Genotype
Humans
Male
Middle Aged
Neuropsychological Tests
Phenotype

Source

Open in PubMed

Identifiers

PMID: 9100151
DOI: 10.1177/089198879701000101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9100151-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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