Article
Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.
Journal of geriatric psychiatry and neurology - 1 Jan 1997
Lopez-Alberola R F, Barker W W, Harwood D G, Loewenstein D A, George-Hyslop P H, Tsuda T, Rogaeva E A, Duara R
Abstract excerpt
The features of Alzheimer's disease (AD) are very heterogenous, and some component of the variability of AD is likely to be related to genetic factors. To investigate this question, we evaluated 19 clinical neuropsychiatric and brain imaging features in 32 familial Alzheimer's disease (FAD) kindred, primarily of late onset. Within families, patients displayed a high degree of phenotypic heterogeneity (PH), which...
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