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Familial Alzheimer's disease. Evidences for clinical and genetic heterogeneity.

Acta neurologica - 1 Dec 1991

Bergamini L, Pinessi L, Rainero I, Brunetti E, Cerrato P, Cosentino L, Vaula G, Bruni A C, Ermio C, Gei G

Abstract excerpt

We report the genealogical, clinical and molecular genetic findings of a new family with autosomal dominant early-onset Alzheimer's disease (FAD) discovered in Torino (Italy). Up to now, the pedigree comprises 1500 members, distributed in 8 generations. 22 patients affected with Alzheimer's disease have been identified. The clinical course of the disease was fairly uniform in all the patients. An high incidence...

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PMID: 1805554

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