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Article

Familial Alzheimer's disease. Evidences for clinical and genetic heterogeneity.

Acta neurologica - 1 Dec 1991

Bergamini L, Pinessi L, Rainero I, Brunetti E, Cerrato P, Cosentino L, Vaula G, Bruni A C, Ermio C, Gei G

Abstract excerpt

We report the genealogical, clinical and molecular genetic findings of a new family with autosomal dominant early-onset Alzheimer's disease (FAD) discovered in Torino (Italy). Up to now, the pedigree comprises 1500 members, distributed in 8 generations. 22 patients affected with Alzheimer's disease have been identified. The clinical course of the disease was fairly uniform in all the patients. An high incidence...

Topics

Adult
Alzheimer Disease
Chromosome Aberrations
Chromosome Disorders
Female
Genes, Dominant
Genetic Carrier Screening
Genetic Markers
Humans
Italy
Phenotype

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PMID: 1805554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1805554-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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