Article
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.
Cancer cell - 1 Mar 2002
Chan Tung O, Rodeck Ulrich, Chan Andrew M, Kimmelman Alec C, Rittenhouse Susan E, Panayotou George, Tsichlis Philip N
Abstract excerpt
Phosphoinositide 3-kinase (PI3K) type IA is a heterodimer of a catalytic subunit, p110, and a regulatory subunit, p85. Here we show that p85 contains a GTPase-responsive domain and an inhibitory domain, which together form a molecular switch that regulates PI3K. H-Ras and Rac1 activate PI3K by targeting the GTPase-responsive domain. The stimulatory effect of these molecules, however, is blocked by the inhibitory...
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