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Article

The dormancy regulator DosR controls ribosome stability in hypoxic mycobacteria.

The Journal of biological chemistry - 6 Jul 2012

Trauner Andrej, Lougheed Kathryn E A, Bennett Mark H, Hingley-Wilson Suzanne M, Williams Huw D

Abstract excerpt

It is thought that during latent infection, Mycobacterium tuberculosis bacilli are retained within granulomas in a low-oxygen environment. The dormancy survival (Dos) regulon, regulated by the response regulator DosR, appears to be essential for hypoxic survival in M. tuberculosis, but it is not known how the regulon promotes survival. Here we report that mycobacteria, in contrast to enteric bacteria, do not form...

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Identifiers

PMID: 22544737
DOI: 10.1074/jbc.M112.364851
PMCID: PMC3390679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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