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Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.

Schizophrenia research - 1 Aug 2010

Shen Yu-Chih, Liao Ding-Lieh, Lu Chao-Lin, Chen Jen-Yeu, Liou Ying-Jay, Chen Tzu-Ting, Chen Chia-Hsiang

Abstract excerpt

OBJECTIVES: Vesicular glutamate transporters (VGLUT1-3) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. In mesencephalic dopamine neuron culture, the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3, have been demonstrated. As related to the dysregulated glutamatergic hypothesis of schizophrenia, the gene encoding VGLUT2 is the most...

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PMID: 20541370
DOI: 10.1016/j.schres.2010.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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