Article
Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia.
Schizophrenia research - 1 Dec 2009
Shen Yu-Chih, Liao Ding-Lieh, Chen Jen-Yeu, Wang Ying-Chieh, Lai I-Ching, Liou Ying-Jay, Chen Yu-Jun, Luu Sy-Ueng, Chen Chia-Hsiang
Abstract excerpt
Dysregulation of glutamate neurotransmission is implicated in the pathphysiology of schizophrenia. Vesicular glutamate transporters (VGLUTs) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. Abnormal VGLUT1 expression has been linked to schizophrenia in postmortem brain studies. The purpose of this study was to investigate the involvement of the human VGLUT1 in the...
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