Article
Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia.
Human molecular genetics - 1 Aug 2011
Sun Chicheng, Cheng Min-Chih, Qin Rosie, Liao Ding-Lieh, Chen Tzu-Ting, Koong Farn-Jong, Chen Gong, Chen Chia-Hsiang
Abstract excerpt
Schizophrenia is a severe chronic mental disorder with a high genetic component in its etiology. Several lines of study have suggested that synaptic dysfunction may underlie the pathogenesis of schizophrenia. Neuroligin proteins function as cell-adhesion molecules at post-synaptic membrane and play critical roles in synaptogenesis and synaptic maturation. In this study, we systemically sequenced all the exons and...
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