Article
Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics.
The European respiratory journal - 1 Jan 2001
Fukunaga K, Asano K, Mao X Q, Gao P S, Roberts M H, Oguma T, Shiomi T, Kanazawa M, Adra C N, Shirakawa T, Hopkin J M, Yamaguchi K
Abstract excerpt
Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthma and the CCR3 gene polymorphisms. Three...
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