Article
Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients.
Mutagenesis - 1 Sept 2010
Obtulowicz Tomasz, Swoboda Maja, Speina Elzbieta, Gackowski Daniel, Rozalski Rafal, Siomek Agnieszka, Janik Justyna, Janowska Beata, Ciesla Jaroslaw M, Jawien Arkadiusz, Banaszkiewicz Zbigniew, Guz Jolanta, Dziaman Tomasz, Szpila Anna, Olinski Ryszard, Tudek Barbara
Abstract excerpt
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and healthy volunteers (controls, n = 99), we measured: vitamins A, C and E in blood plasma, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanine...
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