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Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

7 Jun 2010

Abstract excerpt

Glioblastoma multiforme (GBM) is a fatal primary brain tumor harboring myriad genetic and epigenetic alterations. The recent multidimensional analysis of the GBM genome has provided a more complete view of the landscape of such alterations and their linked pathways. This effort has demonstrated that certain pathways are universally altered, but that the specific genetic events altered within each pathway can vary...

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PMID: 20534551
DOI: 10.1073/pnas.1001613107

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