Article
Functional genomics identifies new synergistic therapies for retinoblastoma
22 Jun 2020
Abstract excerpt
Abstract Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily withRB1loss or, rarely,MYCNamplification, but the critical downstream networks are incompletely understood. We set out to uncover perturbed molecular hubs, identify synergistic drug combinations to target these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.