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Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.

Neoplasma - 1 Jan 2010

Soucek P, Susova S, Mohelnikova-Duchonova B, Gromadzinska J, Moraviec-Sztandera A, Vodicka P, Vodickova L

Abstract excerpt

The question of susceptibility to squamous cell carcinoma of head and neck (SCCHN) in the environmental context was addressed by analysis of functional polymorphisms in enzymes metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT1, ADH1B and ADH1C). Case-control study of 122 age- and sex-matched pairs of subjects was performed using so far unexplored Central European...

Topics

Adult
Aged
Aged, 80 and over
Alcohol Dehydrogenase
Aryl Hydrocarbon Hydroxylases
Carcinoma, Squamous Cell
Case-Control Studies
Cytochrome P-450 CYP1B1
Cytochrome P-450 Enzyme System
Europe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genotype

Head and Neck Neoplasms

Humans

Logistic Models

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Source

Identifiers

PMID: 20568895
DOI: 10.4149/neo_2010_05_415

Genes

NQO1
EPHX1
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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