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Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways

9 Jun 2010

Abstract excerpt

Selectively targeting cancer stem cells (CSC) or tumor-initiating cells (TIC; from this point onward referred to as CSCs) with novel agents is a rapidly emerging field of oncology. Our knowledge of CSCs and their niche microenvironments remains a nascent field. CSC's critical dependence upon self-renewal makes these regulatory signaling pathways ripe for the development of experimental therapeutic agents....

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PMID: 20530695
DOI: 10.1158/1078-0432.ccr-09-2934

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