Article
Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors.
Experimental hematology - 1 Jan 2000
Zhou Chengjing, Uluisik Rizvan, Rowley Jesse W, David Camille, Jones Courtney L, Scharer Christopher D, Noetzli Leila, Fisher Marlie H, Kirkpatrick Gregory D, Bark Katrina, Boss Jeremy M, Henry Curtis J, Pietras Eric M, Di Paola Jorge, Porter Christopher C
Abstract excerpt
Germline mutations in ETV6 are associated with a syndrome of thrombocytopenia and leukemia predisposition, and ETV6 is among the most commonly mutated genes in leukemias, especially childhood B-cell acute lymphoblastic leukemia. However, the mechanisms underlying disease caused by ETV6 dysfunction are poorly understood. To address these gaps in knowledge, using CRISPR/Cas9, we developed a mouse model of the most...
Topics
- Animals
- Germ Cells
- Germ-Line Mutation
- Humans
- Inflammation
- Mice
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins c-ets