Article
gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans.
Developmental biology - 15 Dec 2000
Friedman L, Santa Anna-Arriola S, Hodgkin J, Kimble J
Abstract excerpt
The gon-4 gene is required for gonadogenesis in the nematode Caenorhabditis elegans. Normally, two precursor cells, Z1 and Z4, follow a reproducible pattern of cell divisions to generate the mature somatic gonadal structures (e.g., uterus in hermaphrodites, vas deferens in males). In contrast, in gon-4 mutants, the Z1/Z4 cell lineages are variably aborted in both hermaphrodites and males: Z1 and Z4 divide much...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle Proteins
- Cell Division
- Disorders of Sex Development
- Embryo, Nonmammalian
- Female
- Genes, Helminth
- Genes, Reporter
- Green Fluorescent Proteins
- Helminth Proteins