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Article

Zebrafish gon4la mutants recapitulate human GON4L-related growth disorders and reveal novel metabolic organs abnormalities.

Scientific reports - 4 Apr 2026

Tsai Su-Mei, Hsu Chia-Hao, Chiang I-Chieh, Liao Wei-Neng, Chen Jen-Kun, Jiang Yun-Jin

Abstract excerpt

Biallelic mutations in human GON4L have been linked to short stature, craniofacial abnormalities, and microcephaly, yet the underlying mechanisms remain unclear. GON4L is a nuclear protein composed of a YY1AP1-like region, two PAH domains, and one SANT domain, all implicated in transcriptional or chromatin regulation. Here, we define the function of Gon4la (a zebrafish ortholog of human GON4L) in post-embryonic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41935090
DOI: 10.1038/s41598-026-44674-3
PMCID: PMC13212936

Genes

GON4L
YY1AP1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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