Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pontin is essential for murine hematopoietic stem cell survival.

Haematologica - 1 Sept 2012

Bereshchenko Oxana, Mancini Elena, Luciani Luisa, Gambardella Adriana, Riccardi Carlo, Nerlov Claus

Abstract excerpt

Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression. While Pontin is known to be essential in yeast, fruit flies and frogs, its physiological role in mammalian organisms remains to be determined. We here find that Pontin is highly expressed in embryonic stem cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATPases Associated with Diverse Cellular Activities
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to DNA Helicases

Share to Embryonic Stem Cells

Share to Flow Cytometry

Share to Hematopoietic Stem Cells

Share to Integrases

Source

Open in PubMed Open full text

Identifiers

PMID: 22371176
DOI: 10.3324/haematol.2011.060251
PMCID: PMC3436228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pontin is essential for murine hematopoietic stem cell survival.PMID 22371176Read ↗

Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male miceSemantic proximity Read ↗

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Semantic proximity Read ↗

Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.Semantic proximity Read ↗

Life beyond cleavage: the case of Ago2 and hematopoiesis.Semantic proximity Read ↗

A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.Semantic proximity Read ↗

<i>rapunzel5</i> is necessary for normal hematopoietic development in zebrafishSemantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells.Semantic proximity Read ↗

A mouse model of ZTTK syndrome reveals indispensable SON functions in organ development and hematopoiesisSemantic proximity Read ↗

Mammalian Pabpc4 is non-essential for development, but has roles in growth, post-natal survival and haematopoiesisSemantic proximity Read ↗

A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.Semantic proximity Read ↗

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.