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Article

Pontin is essential for murine hematopoietic stem cell survival.

Haematologica - 1 Sept 2012

Bereshchenko Oxana, Mancini Elena, Luciani Luisa, Gambardella Adriana, Riccardi Carlo, Nerlov Claus

Abstract excerpt

Pontin is a highly conserved DNA helicase/ATPase which is a component of several macromolecular complexes with functions that include DNA repair, telomere maintenance and tumor suppression. While Pontin is known to be essential in yeast, fruit flies and frogs, its physiological role in mammalian organisms remains to be determined. We here find that Pontin is highly expressed in embryonic stem cells and...

Topics

ATPases Associated with Diverse Cellular Activities
Animals
Apoptosis
Blotting, Western
Bone Marrow
Cell Differentiation
Cell Survival
Cells, Cultured
DNA Helicases
Embryonic Stem Cells
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoietic Stem Cells

Integrases

Mice

Mice, Knockout

Phenotype

Source

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Identifiers

PMID: 22371176
DOI: 10.3324/haematol.2011.060251
PMCID: PMC3436228

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