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Article

Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension

7 Feb 2019

Abstract excerpt

In pulmonary arterial hypertension (PAH), the Warburg effect (glycolytic shift) and mitochondrial fission are determinants of phenotype alterations characteristic of the disease, such as proliferation, apoptosis resistance, migration, endothelial-mesenchymal transition, and extracellular matrix stiffness. Current therapies, focusing largely on vasodilation and antithrombotic protection, do not restore these...

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PMID: 30727752
DOI: 10.1161/atvbaha.118.312262

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