Article
Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs.
Carcinogenesis - 1 Aug 2010
Izumiya Masashi, Okamoto Koji, Tsuchiya Naoto, Nakagama Hitoshi
Abstract excerpt
MicroRNA (miRNA) is a class of non-coding RNAs that represses expression of target messenger RNAs posttranscriptionally. A growing body of evidence supports their roles in various normal cellular processes, as well as in pathological conditions, such as cancer. We established a functional screening assay that enables high-throughput identification of miRNAs that have a role in cancer phenotypes of interest, via...
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