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The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines

26 Jan 2012

Abstract excerpt

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus,...

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PMID: 22291592
DOI: 10.1371/journal.ppat.1002484

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