Article
Discovering cancer vulnerabilities using high-throughput micro-RNA screening.
Nucleic acids research - 15 Dec 2017
Nikolic Iva, Elsworth Benjamin, Dodson Eoin, Wu Sunny Z, Gould Cathryn M, Mestdagh Pieter, Marshall Glenn M, Horvath Lisa G, Simpson Kaylene J, Swarbrick Alexander
Abstract excerpt
Micro-RNAs (miRNAs) are potent regulators of gene expression and cellular phenotype. Each miRNA has the potential to target hundreds of transcripts within the cell thus controlling fundamental cellular processes such as survival and proliferation. Here, we exploit this important feature of miRNA networks to discover vulnerabilities in cancer phenotype, and map miRNA-target relationships across different cancer...
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