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Article

A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer.

Nucleic acids research - 1 Oct 2010

Yokoyama Noriko N, Pate Kira T, Sprowl Stephanie, Waterman Marian L

Abstract excerpt

Lymphoid enhancer factor 1 (LEF-1) mediates Wnt signaling via recruitment of β-catenin to target genes. The LEF1 gene is aberrantly transcribed in colon cancers because promoter 1 (P1) is a Wnt target gene and is activated by TCF-β-catenin complexes. A second promoter in intron 2 (P2) produces do...

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Identifiers

PMID: 20525792
DOI: 10.1093/nar/gkq492
PMCID: PMC2965227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20525792-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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