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Article

Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.

Cancer science - 1 Nov 2016

Kakizaki Fumihiko, Sonoshita Masahiro, Miyoshi Hiroyuki, Itatani Yoshiro, Ito Shinji, Kawada Kenji, Sakai Yoshiharu, Taketo M Mark

Abstract excerpt

We recently found that the product of the AES gene functions as a metastasis suppressor of colorectal cancer (CRC) in both humans and mice. Expression of amino-terminal enhancer of split (AES) protein is significantly decreased in liver metastatic lesions compared with primary colon tumors. To investigate its downregulation mechanism in metastases, we searched for transcriptional regulators of AES in human CRC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27561171
DOI: 10.1111/cas.13063
PMCID: PMC5132282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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