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Article

Design of a non-glycosylated outer domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies.

The Journal of biological chemistry - 27 Aug 2010

Bhattacharyya Sanchari, Rajan Roshan Elizabeth, Swarupa Yalla, Rathore Ujjwal, Verma Anjali, Udaykumar Ranga, Varadarajan Raghavan

Abstract excerpt

The outer domain (OD) of the HIV-1 envelope glycoprotein gp120 is an important target for vaccine design as it contains a number of conserved epitopes, including a large fraction of the CD4 binding site. Attempts to design OD-based immunogens in the past have met with little success. We report the design and characterization of an Escherichia coli-expressed OD-based immunogen (OD(EC)), based on the sequence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20558728
DOI: 10.1074/jbc.M110.152272
PMCID: PMC2930709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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