Article
Molecular and Physicochemical Factors Governing Solubility of the HIV gp41 Ectodomain.
Biophysical journal - 23 Aug 2016
Manssour-Triedo Fadia, Crespillo Sara, Morel Bertrand, Casares Salvador, Mateo Pedro L, Notka Frank, Roger Marie G, Mouz Nicolas, El-Habib Raphaelle, Conejero-Lara Francisco
Abstract excerpt
The HIV gp41 ectodomain (e-gp41) is an attractive target for the development of vaccines and drugs against HIV because of its crucial role in viral fusion to the host cell. However, because of the high insolubility of e-gp41, most biophysical and structural analyses have relied on the production of truncated versions removing the loop region of gp41 or the utilization of nonphysiological solubilizing conditions....
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