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Article

Designing a soluble near full-length HIV-1 gp41 trimer.

The Journal of biological chemistry - 4 Jan 2013

Gao Guofen, Wieczorek Lindsay, Peachman Kristina K, Polonis Victoria R, Alving Carl R, Rao Mangala, Rao Venigalla B

Abstract excerpt

The HIV-1 envelope spike is a trimer of heterodimers composed of an external glycoprotein gp120 and a transmembrane glycoprotein gp41. gp120 initiates virus entry by binding to host receptors, whereas gp41 mediates fusion between viral and host membranes. Although the basic pathway of HIV-1 entry has been extensively studied, the detailed mechanism is still poorly understood. Design of gp41 recombinants that...

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Identifiers

PMID: 23184960
DOI: 10.1074/jbc.M112.424432
PMCID: PMC3537018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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