Article
No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes.
BMC medical genetics - 4 Jun 2010
Müssig Karsten, Machicao Fausto, Machann Jürgen, Schick Fritz, Claussen Claus D, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald
Abstract excerpt
BACKGROUND: The nuclear receptor NR4A1 is implicated in metabolic regulation in insulin-sensitive tissues, such as liver, adipose tissue, and skeletal muscle. Functional loss of NR4A1 results in insulin resistance and enhanced intramuscular and hepatic lipid content. Therefore, we investigated in...
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