Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes.

BMC medical genetics - 4 Jun 2010

Müssig Karsten, Machicao Fausto, Machann Jürgen, Schick Fritz, Claussen Claus D, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

BACKGROUND: The nuclear receptor NR4A1 is implicated in metabolic regulation in insulin-sensitive tissues, such as liver, adipose tissue, and skeletal muscle. Functional loss of NR4A1 results in insulin resistance and enhanced intramuscular and hepatic lipid content. Therefore, we investigated in a cohort of white European subjects at increased risk for type 2 diabetes whether genetic variation within the NR4A1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Biochemical Phenomena

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose Clamp Technique

Share to Glucose Tolerance Test

Share to Insulin

Share to Insulin Resistance

Share to Insulin Secretion

Source

Open in PubMed Open full text

Identifiers

PMID: 20525362
DOI: 10.1186/1471-2350-11-84
PMCID: PMC2894787

Genes

MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes.PMID 20525362Read ↗

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.Semantic proximity Read ↗

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.Semantic proximity Read ↗

Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.Semantic proximity Read ↗

Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.Semantic proximity Read ↗

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.Semantic proximity Read ↗

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations.Semantic proximity Read ↗

Variants in the CNR1 and the FAAH genes and adiposity traits in the community.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.Semantic proximity Read ↗

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.Semantic proximity Read ↗

RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.Semantic proximity Read ↗

Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.