Article
Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.
BMC medical genetics - 26 Dec 2008
Andreasen Camilla Helene, Mogensen Mette Sloth, Borch-Johnsen Knut, Sandbaek Annelli, Lauritzen Torsten, Almind Katrine, Hansen Lars, Jørgensen Torben, Pedersen Oluf, Hansen Torben
Abstract excerpt
BACKGROUND: Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP...
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