Article
Analyzing complex traits with congenic strains.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2010
Shao Haifeng, Sinasac David S, Burrage Lindsay C, Hodges Craig A, Supelak Pamela J, Palmert Mark R, Moreno Carol, Cowley Allen W, Jacob Howard J, Nadeau Joseph H
Abstract excerpt
Congenic strains continue to be a fundamental resource for dissecting the genetic basis of complex traits. Traditionally, genetic variants (QTLs) that account for phenotypic variation in a panel of congenic strains are sought first by comparing phenotypes for each strain to the host (reference) strain, and then by examining the results to identify a common chromosome segment that provides the best match between...
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