Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

Abstract excerpt

Significance Mammals form the final numbers of nephrons, the functional units of their kidneys, before or within a few days after birth. This initial endowment declines throughout life without the ability to replace nephrons lost to injury. Therefore, humans with low nephron numbers (such as premature infants) have higher rates of kidney disease in adulthood. Here we report that partial reduction in hamartin...

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