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Impact of the <i>MDM2</i> SNP309 and <i>p53</i> Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome

28 Oct 2005

Abstract excerpt

Li-Fraumeni syndrome, resulting from p53 (TP53) germline mutations, represents one of the most devastating genetic predispositions to cancer. Recently, the MDM2 SNP309 (T-->G variation) was shown to be associated with accelerated tumour formation in p53 mutation carriers. The impact of the common p53 codon 72 polymorphism on cancer risk remains controversial. We therefore investigated the effect of these two...

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PMID: 16258005
DOI: 10.1136/jmg.2005.037952

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