Article
Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein.
The ISME journal - 1 Dec 2010
Sota Masahiro, Yano Hirokazu, Hughes Julie M, Daughdrill Gary W, Abdo Zaid, Forney Larry J, Top Eva M
Abstract excerpt
The ability of bacterial plasmids to adapt to novel hosts and thereby shift their host range is key to their long-term persistence in bacterial communities. Promiscuous plasmids of the incompatibility group P (IncP)-1 can colonize a wide range of hosts, but it is not known if and how they can contract, shift or further expand their host range. To understand the evolutionary mechanisms of host range shifts of...
Topics
- Adaptation, Biological
- Bacterial Proteins
- DNA Helicases
- DNA Replication
- DNA, Bacterial
- Evolution, Molecular
- Genetic Fitness
- Mutation
- Plasmids
- Pseudomonas aeruginosa
- Replicon
- Sequence Analysis, DNA
- Shewanella
- Trans-Activators