Article
The evolution of infectious transmission promotes the persistence of mcr-1 plasmids.
mBio - 31 Aug 2023
Yang Jun, Wu Renjie, Xia Qiang, Yu Jingjing, Yi Ling-Xian, Huang Ying, Deng Meixin, He Wan-Yun, Bai Yuman, Lv Luchao, Burrus Vincent, Wang Chengzhen, Liu Jian-Hua
Abstract excerpt
Conjugative plasmids play a vital role in bacterial evolution and promote the spread of antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the host bacteria. Compensatory mutations are known as an effective evolutionary solution to reduce the fitness cost and improve plasmid persistence. However, whether the plasmid transmission by conjugation is sufficient to improve...
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