The ADORA2A TT Genotype Is Associated with Anti-Inflammatory Effects of Caffeine in Response to Resistance Exercise and Habitual Coffee Intake.

doi:10.3390/nu15071634

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The ADORA2A TT Genotype Is Associated with Anti-Inflammatory Effects of Caffeine in Response to Resistance Exercise and Habitual Coffee Intake.

Nutrients - 28 Mar 2023

Rahimi Mohammad Rahman, Semenova Ekaterina A, Larin Andrey K, Kulemin Nikolay A, Generozov Edward V, Łubkowska Beata, Ahmetov Ildus I, Golpasandi Hadi

Abstract excerpt

Caffeine is an adenosine A2A receptor (ADORA2A) antagonist with ergogenic and anti-inflammatory effects. Previous studies have reported that the ADORA2A gene regulates glutamate metabolism and immune responses, with the ADORA2A rs5751876 TT genotype (with high sensitivity to caffeine) showing larger ergogenic effect following caffeine ingestion. We therefore hypothesized that the TT genotype would be associated...

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PMID: 37049474
DOI: 10.3390/nu15071634
PMCID: PMC10097079

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