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Article

Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans.

Genetics - 1 Aug 2010

Kim Min Su, Ko Young-Joon, Maeng Shinae, Floyd Anna, Heitman Joseph, Bahn Yong-Sun

Abstract excerpt

Carbon dioxide (CO(2)) sensing and metabolism via carbonic anhydrases (CAs) play pivotal roles in survival and proliferation of pathogenic fungi infecting human hosts from natural environments due to the drastic difference in CO(2) levels. In Cryptococcus neoformans, which causes fatal fungal meningoencephalitis, the Can2 CA plays essential roles during both cellular growth in air and sexual differentiation of...

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Identifiers

PMID: 20516494
DOI: 10.1534/genetics.110.118315
PMCID: PMC2927750

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