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Article

A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2011

Leng Lin, Chen Liang, Fan Juan, Greven Dorothee, Arjona Alvaro, Du Xin, Austin David, Kashgarian Michael, Yin Zhinan, Huang Xiao R, Lan Hui Y, Lolis Elias, Nikolic-Paterson David, Bucala Richard

Abstract excerpt

Autoimmunity leads to the activation of innate effector pathways, proinflammatory cytokine production, and end-organ injury. Macrophage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates the recruitment and retention of monocytes via CD74 and associated chemokine receptors, and it has a role in the maintenance of B lymphocytes. High-expression MIF alleles also are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21106847
DOI: 10.4049/jimmunol.1001767
PMCID: PMC3124407

Genes

MIF
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.PMID 21106847Read ↗

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Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice.Semantic proximity Read ↗

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