Article
Biomarkers in the era of personalized medicine - a multiplexed SNP assay using capillary electrophoresis for assessing drug metabolism capacity.
Scandinavian journal of clinical and laboratory investigation. Supplementum - 1 Jan 2010
Rai Alex J, Yee Jessica, Fleisher Martin
Abstract excerpt
Pharmacogenetics is the study of genetic differences in an individual that leads to variability in drug response. Single-nucleotide polymorphisms (SNPs) prove to be important determinants in evaluating and predicting a patient's response to certain medications and risk of adverse events. The Cytochrome P450 2D6 (CYP2D6) gene is particularly important in the metabolism of many clinically prescribed drugs. In this...
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