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Article

Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes.

Acta neuropathologica - 1 Aug 2010

Seiz Marcel, Tuettenberg Jochen, Meyer Jochen, Essig Marco, Schmieder Kirsten, Mawrin Christian, von Deimling Andreas, Hartmann Christian

Abstract excerpt

The current WHO classification of brain tumors defines gliomatosis cerebri (GC) as an extensively infiltrating astrocytic glioma involving at least three cerebral lobes. The relation of GC to diffuse astrocytomas and glioblastoma is uncertain. Due to malignant biological behavior, GC is allotted to WHO grade III. Recent reports showed IDH1 mutations in astrocytic and oligodendroglial tumors WHO grades II and III...

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Source

Identifiers

PMID: 20514489
DOI: 10.1007/s00401-010-0701-2

Genes

IDH1

Provenance

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