Article
Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk.
Oncology reports - 1 Jul 2010
Gao Weimin, Romkes Marjorie, Zhong Shilong, Nukui Tomoko, Persad Raj A, Smith Patrick J B, Branch Robert, Keohavong Phouthone
Abstract excerpt
Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk for mutations in the p53 tumor suppressor gene in lung tumors. To evaluate whether these gene...
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