Article
Genomic sequence comparison, promoter activity, SNP detection of RIG-I gene and association with resistance/susceptibility to grass carp reovirus in grass carp (Ctenopharyngodon idella).
Developmental and comparative immunology - 1 Apr 2013
Wan Quanyuan, Su Jianguo, Chen Xiaohui, Yang Chunrong, Chen Lijun, Yan Nana, Zhang Yixuan
Abstract excerpt
As an intracellular pattern recognition receptor (PRR), retinoic acid-inducible gene-I (RIG-I) is responsible for detection of nucleic acids from pathogens in infected cells and activation of type I interferon (IFN). In the present study, the 5'-flanking region, introns and single nucleotide polymorphisms (SNPs) of CiRIG-I (Ctenopharyngodon idella RIG-I) were identified and characterized. The genomic CiRIG-I was...
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