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Article

Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.

International journal of oncology - 1 Mar 2016

Kong Lingxin, Guo Sufen, Liu Chunfeng, Zhao Yiling, Feng Chong, Liu Yunshuang, Wang Tao, Li Caijuan

Abstract excerpt

The formation of EMT and EMT-induced CSC-like phenotype is crucial for the metastasis of tumor cells. The stromal cell-derived factor-1 (SDF-1) is upregulated in various human carcinomas, which is closely associated with proliferation, migration, invasion and prognosis of malignancies. However, limited attention has been directed towards the effect of SDF-1 on epithelial to mesenchymal transition (EMT) or cancer...

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Identifiers

PMID: 26782945
DOI: 10.3892/ijo.2016.3343

Genes

SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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