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Article

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

The Journal of biological chemistry - 30 Jul 2010

Karousou Eugenia, Kamiryo Masaru, Skandalis Spyros S, Ruusala Aino, Asteriou Trias, Passi Alberto, Yamashita Hidetoshi, Hellman Ulf, Heldin Carl-Henrik, Heldin Paraskevi

Abstract excerpt

Hyaluronan is a component of the extracellular matrix, which affects tissue homeostasis. In this study, we investigated the regulatory mechanisms of one of the hyaluronan-synthesizing enzymes, HAS2. Ectopic expression of Flag- and 6myc-HAS2 in COS-1 cells followed by immunoprecipitation and immun...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20507985
DOI: 10.1074/jbc.M110.127050
PMCID: PMC2911313

Genes

HAS2
HAS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20507985-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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