Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HYAL2, a Human Gene Expressed in Many Cells, Encodes a Lysosomal Hyaluronidase with a Novel Type of Specificity

1 Aug 1998

Abstract excerpt

Using Expressed Sequence Tags (ESTs) deposited in the data banks, a cDNA has been assembled that encodes a protein related to the hyaluronidases from bee venom and mammalian sperm. Expression of this cDNA yielded a polypeptide termed HYAL2, which is located in lysosomes. The HYAL2 protein was shown to have hyaluronidase activity below pH 4. However, it only hydrolyzed hyaluronan of high molecular mass from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Structural Characterization
Share to Proteoglycans and glycosaminoglycans research
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9712871
DOI: 10.1074/jbc.273.35.22466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HYAL2, a Human Gene Expressed in Many Cells, Encodes a Lysosomal Hyaluronidase with a Novel Type of SpecificityPMID 9712871Read ↗

Genetic Deficiencies of Hyaluronan DegradationSemantic proximity Read ↗

Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?Semantic proximity Read ↗

Mutations in <i>HYAL1</i> , a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IXSemantic proximity Read ↗

Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.Semantic proximity Read ↗

Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for jaagsiekte sheep retrovirus.Semantic proximity Read ↗

Mammalian hyaluronan synthases: investigation of functional relationships in vivo.Semantic proximity Read ↗

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.Semantic proximity Read ↗

Elucidating the clinical spectrum and molecular basis of HYAL2 deficiency.Semantic proximity Read ↗

Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.Semantic proximity Read ↗

Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21.Semantic proximity Read ↗

Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction.Semantic proximity Read ↗

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.