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Article

Mutation of two intramembrane polar residues conserved within the hyaluronan synthase family alters hyaluronan product size.

The Journal of biological chemistry - 28 Apr 2006

Kumari Kshama, Baggenstoss Bruce A, Parker Andria L, Weigel Paul H

Abstract excerpt

We identified two conserved polar amino acids within different membrane domains (MD) of Streptococcus equisimilis hyaluronan synthase (seHAS), Lys48 in MD2 and Glu327 in MD4. In eukaryotic HASs, the position of the Glu is very similar and the Lys is replaced by a conserved polar Gln. To assess whether Lys48 and Glu327 interact or influence seHAS activity, we investigated the effects of changing Lys48 to Arg or...

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Identifiers

PMID: 16505475
DOI: 10.1074/jbc.M600727200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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