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Optimization of adeno-associated virus (AAV) gene delivery into human bone marrow stem cells (hBMSCs)

1 Feb 2023

Abstract excerpt

Background: Efficiently delivering nucleic acid into mammalian cells is essential to overexpress genes for assessing gene functions. Human bone marrow stem cells (hBMSCs) are the most studied tissue-derived stem cells. Adeno-associated viruses (AAVs) have been used to deliver DNA into hBMSCs for various purposes. Current literature reported that transduction efficiencies of up to 65% could be achieved by AAV gene...

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PMID: 36761253
DOI: 10.21037/sci-2022-042

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