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Article

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2011

Petrs-Silva Hilda, Dinculescu Astra, Li Qiuhong, Deng Wen-Tao, Pang Ji-Jing, Min Seok-Hong, Chiodo Vince, Neeley Andy W, Govindasamy Lakshmanan, Bennett Antonette, Agbandje-McKenna Mavis, Zhong Li, Li Baozheng, Jayandharan Giridhara R, Srivastava Arun, Lewin Alfred S, Hauswirth William W

Abstract excerpt

Vectors based on adeno-associated virus serotype 2 (AAV2) have been used extensively in many gene-delivery applications, including several successful clinical trials for one type of Leber congenital amaurosis in the retina. Many studies have focused on improving AAV2 transduction efficiency and c...

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Identifiers

PMID: 21045809
DOI: 10.1038/mt.2010.234
PMCID: PMC3034844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21045809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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