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An evolved AAV variant enables efficient genetic engineering of murine T cells

1 Jan 2023

Abstract excerpt

Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin efficiencies, but the tropism of current AAV serotypes restricts their use to human T cells employed in immunodeficient mouse models. To enable targeted knockins in murine T...

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PMID: 36638795
DOI: 10.1016/j.cell.2022.12.022

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