Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of human cytochrome P450 2E1 electrocatalytic response as a result of unique orientation on gold electrodes.

Analytical chemistry - 15 Jun 2010

Mak Lok Hang, Sadeghi Sheila J, Fantuzzi Andrea, Gilardi Gianfranco

Abstract excerpt

Oriented immobilization of human cytochrome P450 2E1 and its catalytic activity by direct electrochemistry was achieved by engineering two multisite mutants of P450 2E1: MUT261 (C268S-C480S-C488S) and MUT268 (C261S-C480S-C488S). Here, all the exposed cysteines are mutated into serines, with the exception of one (C261 for MUT261 and C268 for MUT268) that is able to link covalently to a modified gold electrode. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cytochrome P-450 CYP2E1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrochemistry

Share to Electrodes

Share to Escherichia coli

Share to Gene Expression

Share to Models, Molecular

Source

Identifiers

PMID: 20507171
DOI: 10.1021/ac101072h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of human cytochrome P450 2E1 electrocatalytic response as a result of unique orientation on gold electrodes.PMID 20507171Read ↗

Orientation-dependent electron transport in a single redox protein.Semantic proximity Read ↗

Protein and electrode engineering for the covalent immobilization of P450 BMP on gold.Semantic proximity Read ↗

Enhancement of direct electron transfer in graphene bioelectrodes containing novel cytochrome c553 variants with optimized heme orientation.Semantic proximity Read ↗

Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64.Semantic proximity Read ↗

Covalent conjugation of single-walled carbon nanotube with CYP101 mutant for direct electrocatalysis.Semantic proximity Read ↗

Self-assembled monolayers of Aβ peptides on Au electrodes: an artificial platform for probing the reactivity of redox active metals and cofactors relevant to Alzheimer's disease.Semantic proximity Read ↗

Modification of galactitol dehydrogenase from Rhodobacter sphaeroides D for immobilization on polycrystalline gold surfaces.Semantic proximity Read ↗

Surface-modified mutants of cytochrome P450cam: enzymatic properties and electrochemistry.Semantic proximity Read ↗

Electroactive multilayer assemblies of bilirubin oxidase and human cytochrome C mutants: insight in formation and kinetic behavior.Semantic proximity Read ↗

Disentangling electron tunneling and protein dynamics of cytochrome c through a rationally designed surface mutation.Semantic proximity Read ↗

Directed evolution of P450cin for mediated electron transfer.Semantic proximity Read ↗

Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.