Article
Data analysis issues for allele-specific expression using Illumina's GoldenGate assay.
BMC bioinformatics - 26 May 2010
Ritchie Matthew E, Forrest Matthew S, Dimas Antigone S, Daelemans Caroline, Dermitzakis Emmanouil T, Deloukas Panagiotis, Tavaré Simon
Abstract excerpt
BACKGROUND: High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use of Illumina's GoldenGate BeadArray technology to measure ASE. This platform exploits coding SNPs to obtain relative expression measurements for alleles at approximately 1500 positions in the genome....
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